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KMID : 0043319960190030207
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Archives of Pharmacal Research
1996 Volume.19 No. 3 p.207 ~ p.212
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Antitumor Components of Agrocybe cylindracea
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Hyun Jin-Won
Kim Chae-Kyun
Park Seol-Hee
Yoon Jong-Myung
Shim Mi-Ja
Kang Chary-Yuil
Choi Eung-Chil
Kim Byung-Kak
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Abstract
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To find pharmacologically active components of Agrocybe cylin(Iracea, its basidiocarps were extracted with water. The extracts were separated by DEAE cellulose column chromatography, Sepharose CL-4B gel filtration, and Concanavalin A-Sepharose 4B affinity chromatography. Among the obtained fractions from A, cylinclracea, fraction IN which was the neutral proteinbound-polysaccharide fraction exhibited a marked antitumor activity and it was tentatively named "Cylindan". It showed about 70% of tumor inhibition against the solid form of sarcoma 180 when a dose of 30 mg/kg/day was intraperitoneally injected into ICR mice. When each fraction was examined by chemical analysis, Cylindan consisted of 85% polysaccharide, 3% protein and 1% hexosamine. Its polysaccharide moiety contained glucose, mannose, fucose and galactose and its protein moiety contained the comparatively large amounts of aspartic acid and glycine, and other 11 amino acids.
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KEYWORD
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Basidiomycete, Agrocybe cylindracea, Edible mushrooms, Protein bound -po-lysaccharides, Antitumor activity
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